Randomized clinical trials
The randomized clinical trials section is produced following a review of the content of the best surgical journals published in English worldwide. The section editor is Jonothan Earnshaw, Director of the BJS Academy and Consultant Vascular Surgeon at Gloucestershire Hospitals NHS Foundation Trust, UK.
Morbidity after mechanical bowel preparation and oral antibiotics prior to rectal resection. The MOBILE2 randomized clinical trial.
Koskenvuo L, Lunkka P, Varpe P, Hyoty M, Satokari R, Haapamaki C et al.
25 September 2024
Doublet chemotherapy, triplet chemotherapy, or doublet chemotherapy combined with radiotherapy as neoadjuvant treatment for locally advanced oesophageal cancer (JCOG1109 NExT): a randomised, controlled, open-label, phase 3 trial.
Kato K, Machida R, Ito Y, Daiko H, Ozawa S, Ogata T et al, on behalf of the JCOG1109 investigators.
3 November 2024
Prophylactic abdominal drainage after distal pancreatectomy (PANDORINA): an international, multicentre, open-label, randomised controlled, non-inferiority trial.
van Bodegraven EA, BalduzzI A, van Ramshorst TME, Malleo G, Vissers FL, van Hilst J et al, for the Dutch Pancreatic Cancer Group.
3 November 2024
Three-year outcomes of oral antibiotics vs intravenous and oral antibiotics for uncomplicated acute appendicitis. A secondary analysis of the APPAC II randomized clinical trial.
Selänne L, Haijanen J, Sippola S, Hurme S, Rautio T, Nordström P et al.
3 November 2024
Effect of robotic versus open pancreaticoduodenectomy on postoperative length of hospital stay and complications for pancreatic head or periampullary tumours: a multicentre, open-label randomised controlled trial.
Liu Q, Li M, Gao Y, Jiang T, Han B, Zhao G et al.
3 November 2024
Impact of small-bite (5 mm) fascial closure on the incidence of incisional hernia following open colorectal cancer surgery: randomized clinical trial
Ozcan C, Colak T, Turkmenoglu O, Berkesoglu M, Ertas E.
18 September 2024
Ten-year outcomes of a randomized clinical trial of endothermal ablation versus conventional surgery for great saphenous varicose veins
Mohamed AH, Howitt A, Rae S, Cai PL, Hitchman L, Wallace T et al.
18 September 2024
Role of Lugol solution before total thyroidectomy for Graves’ disease: randomized clinical trial
Schiavone D, Crimì F, Cabrelle G, Pennelli G, Sacchi D, Mian C et al.
18 September 2024
Long-term cost-effectiveness of insertion of a biological mesh during stoma-site closure: 5–8-year follow-up of the ROCSS randomized controlled trial
Reinforcement of Closure of Stoma Site (ROCSS) Collaborative and West Midlands Research Collaborative.
18 September 2024
Preoperative high dose of dexamethasone in emergency laparotomy: randomized clinical trial
Cihoric M, Kehlet H, Lauritsen ML, Højlund J, Kanstrup K, Kärnsund S et al.
10 September 2024
Epidural versus patient-controlled intravenous analgesia on pain relief and recovery after laparoscopic gastrectomy for gastric cancer: randomized clinical trial
Kikuchi S, Matsusaki T, Mitsuhashi T, Kuroda S, Kashima H, Takata N et al.
30 August 2024
Adrenalectomy improves body weight, glucose, and blood pressure control in patients with mild autonomous cortisol secretion. Results of a randomized controlled trial by the Co-work Of Adrenal Research (COAR) Study.
Koh J-M, Song K, Kwak MK, Suh S, Kim B-J, Sung T-Y et al.
30 August 2024
Neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer (NORPACT-1): a multicentre, randomised, phase 2 trial.
Labori KJ, Bratlie SO, Andersson B, Angelsen J-H, Biorserud C, Bjornsson B et al, for the Nordic Pancreatic Cancer Trial-1 study group.
30 August 2024
Assessment of laparoscopic indocyanine green tracer-guided lymphadenectomy after neoadjuvant chemotherapy for locally advanced gastric cancer. A randomized controlled trial.
Huang Z-N, Tang Y-H, Zhong Q, Li P, Xie J-W, Wang J-B et al.
30 August 2024
Sacral neuromodulation versus conservative treatment for refractory idiopathic slow-transit constipation. The randomized clinical No.2-Trial.
Heemskerk SC, Dirksen CD, van Kuijk SMJ, Benninga MA, Baeten C, Masclee AAM et al.
30 August 2024
Aspirin vs placebo as adjuvant therapy for breast cancer. The Alliance A011502 randomized trial.
Chen WY, Ballman KV, Partridge AH, Hahn OM, Briccetti FM et al.
16 August 2024
Covered versus bare-metal stenting of the mesenteric arteries in patients with chronic mesenteric ischaemia (CoBaGI): a multicentre, patient-blinded and investigator-blinded, randomised controlled trial.
Terlouw LG, van Dijk LJD, van Noord D, Bakker OJ, Bijdevaate DC, Erler NS et al, on behalf of the Dutch Mesenteric Ischemia Study Group.
16 August 2024
Efficacy and safety of bimekizumab in patients with moderate-to-severe hidradenitis suppurativa (BE HEARD I and BE HEARD II): two 48-week, randomised, double-blind, placebo-controlled, multicentre phase 3 trials.
Kimball AB, Jemec GBE, Sayed CJ, Kirby JS, Prens E, Ingram JR et al.
16 August 2024
Intraoperative Wound Irrigation for the Prevention of Surgical Site Infection After Laparotomy. A randomized clinical trial by CHIR-Net.
Mueller C, Kehl V, Dimpel R, Blankenstein C, Egert-Schwender SE, Strudthoff J, Lock JF et al, for the IOWISI Study Group.
16 August 2024
Temporary portocaval shunt provides superior intraoperative hemodynamics and reduces blood loss and duration of surgery in live donor liver transplantation. A randomized controlled trial.
Kumar M, Patil NS, Mohapatra N, Sindwani G, Dhingra U, Yadav A et al.
Ann Surg 2024; 279: 932-944.
16 August 2024
Upfront endoscopic necrosectomy or step-up endoscopic approach for infected necrotising pancreatitis (DESTIN): a single-blinded, multicentre, randomised trial.
Bang JY, Lakhtakia S, Thakkar S, Buxbaum JL, Waxman I, Sutton B et al, on behalf of the United States Pancreatic Disease Study Group.
16 August 2024